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D., Morley, M., Arany, Z., & Rabinowitz, J. Chen, L., Zhang, Z., Hoshino, A., Zheng, H. M., Pérez-Felpete, N., Fernández-Fernández, C., Donapetry-García, C., & Pazos-García, C. Role of the pyruvate dehydrogenase complex in metabolic remodeling: differential pyruvate dehydrogenase complex functions in metabolism. H., Marzuki, I., Dailami, M., Saputra, H. Circadian regulation of glucose, lipid, and energy metabolism in humans. Poggiogalle, E., Jamshed, H., & Peterson, C. Rajendran, M., Dane, E., Conley, J., & Tantama, M. Metabolic flexibility: hibernation, torpor, and estivation. Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Proses metabolisme asam nukleat melaui proses enzimatik (housekeeping) yang sangat bertanggungjawab terhadap fungsi katabolisme dan anabolisme. Metabolisme asam nukleat melibatkan proses sintesis purin dan pirimidin sebagai nukleotida secara de novo. Sebaliknya anabolisme protein tersebut didasari oleh proses transmisi dan aminasi. Demikian pula pada metabolisme protein yang diawali dengan pemecahan makro molekul dalam bentuk peptida menjadi monomer terkecil (asam amino) secara enzimatis (melibatkan enzim protease) dan menjadi salah satu sumber energi dalam pembentukan ATP untuk perkembangan sel. Sedangkan metabolisme lemak melalui proses asetil-KoA terkarboksilase dan menghasilkan malonil-KoA hingga berlanjut pada proses pembentukan asam lemak melalui proses enzimatis (elongase dan desaturase). Proses metabolisme karbohidrat secara khusus melalui glikolisis, glikogenesis dan glukoneogenesis. Demikian sebaliknya proses anabolisme dapat memanfaatkan derivat makro molekul (asam amino, glukosa, fruktosa, asam lemak) menjadi makro molekul (protein, karbohidrat dan lipid). Katabolisme protein, karbohidrat dan lemak dapat menjadi derivat asam amino, glukosa, gliserol dan asam lemak yang mampu dikonversi menjadi energi maupun cadangan energi untuk proses pertumbuhan dan perkembangan sel. Lintasan tersebut umumnya terjadi pada mitokondria melalui siklus Krebs. Lintasan metabolisme karbohidrat, lipid, protein, asam nukleat terdiri atas tiga bentuk lintasan yakni katabolik, anabolik dan amfibolik. Telaah pustaka yang disajikan dalam review ini bersumber pada jurnal ilmiah maupun buku terakreditasi yang relevan. Artikel review ini mengulas tentang prinsip dan proses metabolisme karbohidrat, lipid, protein dan asam nukeat pada organisme. 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